Dr. Sarah Larsen ~ Medical Intuitive and Energy Healer

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Resources for the Coronavirus or COVID-19

January 30, 2020 by Dr. Sarah Larsen Leave a Comment

May 22, 2020 (Updated)


John Hopkins CoronaVirus updates:
https://coronavirus.jhu.edu/map.html

Coronaviruses have been causing problems in humans for a long time. Though many versions of the virus are known to trigger only mild symptoms such as common colds. However, three recent types of coronavirus have caused deadly diseases – the severe acute respiratory syndrome (SARS) in China in 2002, the Middle East respiratory syndrome (MERS) in Saudi Arabia in 2012, and the current global pandemic, the coronavirus disease (COVID-19), which first emerged in Wuhan City, Hubei Province, in China December 2019.

The impact of the previous coronavirus outbreaks in 2002 and 2012 has been mild compared with the mayhem unleashed by the SARS-CoV-2. Within only a few months, the novel coronavirus has prompted most countries to go into lockdown, dwindling economies, and overwhelming health care systems with the more than 2 million people infected.

Meanwhile, scientists across the globe are racing to understand the SARS-CoV-2-in the hope of finding a treatment or cure. Now, the researchers’ surprise discovery has shed light on the potency of the novel coronavirus is killing powerful immune cells, which are supposed to kill the virus instead.

Novel coronavirus (causing Covid-19 Disease) attacks and destroys T cells, just like HIV
Killer T cells fight the viruses like HIV, novel Corona, and Cancer cells.

It is an important discovery, knowing the effect of the SARS-CoV-2 on T cells, since this may show why the disease is spreading so quickly, and infecting so many across the globe. It also explains why certain vulnerable populations are at a high risk of dying from the infection, including those who are more than 65, those who are immunocompromised, and those with underlying medical conditions like lung disease, heart disease, diabetes, and hypertension.

Further investigation shows that patients who died from COVID-19 had damage to their bodies similar to both SARS and HIV. Also, the team found that unlike HIV that replicates faulty T cells, the coronavirus does not replicate, showing that the T cells and the virus may end up dying together.

Zack Bush M.D. on Del Bigtree

https://www.facebook.com/HighWireTalk/videos/783415185521346/

DOCTOR WHO PREDICTED COVID-19 ANSWERS ALL Triple board-certified M.D., Dr. Zach, joins Del in an evolutionary discussion on why Coronavirus is here, what it’s trying to tell us, and how we emerge from the darkness.

The Coronavirus or COVID-19 is now a global pandemic! Assume you or someone you know and possibly love will get the virus!

Please follow the guidelines offered by CDC, WHO, and Global Recommendations from organizations with great compassion:

Dr. Stefan Bajon translated this from Dr. Aysegül Çoruhlu – A Theory that may help

  • The potential of cell-free hemoglobin (CFH), that is hemoglobin that has escaped from inside erythrocytes, causes Acute respiratory distress syndrome.  by itself.
  • Oxygen deficiency caused by increased methemoglobin
  • Re-oxygenation with methylene blue.

Fact: Findings from intensive care physicians indicate that even COVID-19 patients without respiratory distress suffer from reduced oxygen saturation. These patients can speak comfortably in good humor and do not show any signs of respiratory distress. However, due to their progressively decreasing oxygen saturation, they are considered to require oxygen support and put on ventilators.

This condition has been surprising for intensive care physicians. They started to question whether COVID-19 is really ARDS and pneumonia as originally fathomed. To say the least, the onset of COVID-19 is not compatible with these diagnoses.

Well then, why does oxygen saturation rapidly decrease while the lungs are still functioning?

The publication that could answer this question has arrived. This publication (here) states that the SARS-CoV-2 virus attacks the beta chain of hemoglobin.

What does this mean?

Hemoglobin is the part of erythrocytes that carries oxygen. The hemoglobin molecule is made up of two types of amino acid chains that contain heme groups: alpha and beta. Apart from these chains, the hemoglobin molecule also contains Fe (iron) atoms which allow it to bind and carry oxygen.

The coronavirus attacks and disrupts this structure, preventing it from carrying oxygen.

The heme–Fe²?–O? [heme–iron(II)–oxygen] trio is disrupted.

The iron turns from Fe²? into Fe³?. This is harmful. It can even progress to Fe??, which is the most harmful state of the iron ion.

The disrupted non-functional heme molecules leave the erythrocyte and become what is called “cell-free heme,” and start to circulate around the alveoli. They are now outside and free from the erythrocyte. Normally, these molecules need to be destroyed and cleaned up by macrophages and converted into bilirubin. However, the rapidly increasing cell-free heme (CFH) (and reduced haptoglobin and hemopexin, etc.) increases the amount of CHF in the alveolar space.

The effects of ‘cell-free heme (CFH)’:

  • CFH contributes to the development of acute ARDS.
  • CFH provokes inflammation in the alveoli.
  • CFH exacerbates the cytokine storms.
  • It leads to increased LDH,
  • Increased ferritin (which tries to collect the now free iron atoms), and
  • Increased CRP.

CFH reduces nitric oxide and causes vascular constriction. Nitric oxide is one of the most important vasodilators (or widener of blood vessels).

CFH causes the free iron atoms to oxidize from Fe²? to Fe³? up to Fe??.

The literature indicates that CFH is detected in 80% of all ARDS cases.

So far, we have understood that:

  1. In COVID-19, oxygen deficiency precedes lung failure.
  2. The SARS-CoV-2 virus attacks hemoglobin. The heme and iron in hemoglobin become ‘free.’
  3. Therefore, the capacity of hemoglobin to transport oxygen is reduced.
  4. The free iron atom is converted from its harmless state Fe²? into Fe³? and its most dangerous state, Fe??. This state of iron damages tissues.
  5. Heme circulates outside of erythrocytes in the form of CFH.
  6. CFH provokes severe inflammation in the alveolar endothelium.
  7. Increased CFH is seen in 80% of all ARDS cases.
  8. COVID-19 appears to be some kind of hemolysis.

Next; let’s explain the role of alveolar type II cells that contribute to this picture:

Alveolar Type II Cells:

These cells concern us for several reasons.

  • The type II cells contain the ACE2 receptors.
  • When SARS-CoV-2 attaches to ACE2, it is attacking type II cells.
  • Type II cells can produce hemoglobin!!!
  • Can this phenomenon explain the oxygen deficiency associated with SARS-CoV-2 even before it reaches hemoglobin in the alveolar capillaries?
  • CFH molecules may initially occur and contribute to inflammation in a type II cell-mediated manner. Could this be the beginning of everything?

Let’s go back to oxygen deficiency:

What is methemoglobin?

The oxygen-carrying capacity of hemoglobin depends on the iron having an oxidation state of Fe²?. If the iron in hemoglobin is in the Fe³? state, that molecule is called methemoglobin. This can happen in certain poisonings.

Vitamin C and methylene blue help restore the iron back to the Fe²? state.

Methylene blue has a wide range of applications. Our subject matter is that when methylene blue enters the erythrocyte, it transforms into a material that works as an electron donor. It converts methemoglobin back into hemoglobin. In other words, it allows hemoglobin to bind and carry oxygen again.

It would seem that the initial oxygen deficiency associated with COVID-19 is due to the problems with hemoglobin. Does providing patients with decreased oxygen saturation with immediate ventilation support worsen lung damage? Like intravenous vitamin C treatment, is it possible to utilize the intravenous methylene blue treatment in order to prolong the waiting period?

With love and regards…

https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
Dr. Stefan Bajon
4455 Morena Blvd #106
San Diego, Cal 92117
Natural Medicine Pharmacist
Traditional Naturopath
858-336-7869

………

5 Coronavirus Facts to Use on Anyone Who Isn’t Listening

This is a wake-up call

5 Coronavirus Facts to Use on Anyone Who Isn’t Listening

In this video, you meet Jacqstar Davies.

She and Raul Pardeilhan, her husband are friends, Miracle Makers, and founders of “WE ARE THE MIRACLE”!
They are the solution to the shortage of supplies hospitals and medical personal are experiencing!

#coronavirus #covid19 #2019-NCoVTestKit #ParticulateRespiratorN95 #3PlyDisposableProductionFaceMask #ParticulateRespiratorKN95 #3DNanoFacialMaskN99 #3MCuppedParticulateRespiratorAndSurgicalMask1860 #AntiFluVirusDustProtectionRespiratorKF94 #DisposableMedicalProtectiveClothing #InfraredThermometer #ICUVentilator #SeprayST-30HVentilator #HandAlcoholSanitizer

What is true goodness to you? To me, Teamwork, Creating Order to assist, and being the Cure from your best adaptive intelligence! 

Thank you, family! Thank you for being part of Miracle Makers Academy’s chosen family. You help all of us fulfill our Miracle Making Potential!

Today in the live masterclass and community meeting, we will Answer your Questions:
~Protecting yourself about Covid-19 Disease. 
~How to Protect your Mental Health during this Pandemic 
~ and what you can do to make a difference!! 

Answering your questions and here for you are Miracle Makers Academy
Family members. Members include Medical Doctors, Chiropractors, Lawyers, Homeopathic Doctors, Dog lovers, Energy Healers, Naturopathic Doctors, Filmmakers, Musicians, philanthropists, experts in most fields of studies and people just like you!
As a practicing Medical Intuitive, I trained as a doctor of medicine with a focus on infectious diseases. I am here for you! 

Thank you All for being your own true nature and being willing to be humanitarians, activists, and friends!

Build, grow, and strengthen your Immunity and KEEP BEING A MIRACLE MAKER!

Do not let this or anything else deter you from your joy-filled mission!

4 types of immunity to build:

  • Physical Body Immunity
  • Emotional Immunity
  • Mental Immunity &
  • Spiritual Immunity
https://www.facebook.com/DoctorSarahLarsen/videos/189022142394983/

This is the list I recommended to a lifetime member of Miracle Makers Academy to go over with their primary physician:

Stage 1: Build Your Immunity:
*Vitamin C – 1000 mg. 3X/day
*Vitamin E – 400 I.U., 3X per day and all the Antioxidants you can take
*Beta Carotene or O.P.C.’s or both! – 25,000 I.U., 2X per day
*Jade Screen or Astragalus or Immune+ – 3 tabs, 3X per day empty stomach
*Colostrum – 1 – 2 tabs per day
*A strong mushroom formula (shitake, etc.) – take as directed on the bottle
*Isatis Gold – 3 pills, 3X per day – for bacterial or viral infection
*Lonicera Complex – 4 pills, 4X per day – for the first 2-3 days
*Gentianna Complex – sore or strep throat – 6 pills, 4 X/day
*Oscillococcinum Homeopathic – as directed on the box
*Influenzinum Homeopathic for 2014 flu season – daily and also preventive
*Additional homeopathic remedy: Aconite, Eup perf, Pulsatilla, Nux vom
*Umcka syrup
*Airborne
*Kyolic garlic
*Eat lot’s of cooked garlic and onions and warm soups (miso and chicken)
*Don’t eat frozen, cold foods, ice cream, dairy, sugar, gluten, fried or fatty foods
*2 Tblspns Apple Cider Vinegar in warm water with honey and cayenne 2-3X per day
*Vira-Clear cherry syrup
*Vitamin D3
*Glutathione is important for detoxification

Stage 2: Head Cold:
*Mostly same as above, except oscillococcinum can be replaced with a
more specific homeopathic for your specific symptoms:
*Gelsemium, Arsenicum Alb or Allium Cepa
*Add Emphaplex for lungs, cough, and immunity

Stage 3: The Worst (fever, or other symptoms that won’t stop):
*Mostly same as above, except replace oscillococcinum with either:
*Ferrum Phos 12C for low fever
*Belladonna 30C / 200C for high fever
*Gan Mao Ling or Zhong Gan Ling – 4 pills, 4X per day- fever/chills/achy
*For coughing, add Lung Qi Relief from Kan, Spongia tost 30C or Hepar sulph 30C
*For persistent coughing add Immune+: 4, 3X per day and Respertrol Deficient
*Also Add from APEX: ImmuZyme and XViromin and Liquid Vit D

Prevention:
In addition to many of the suggestions for Stage 1, the following is an excellent preventative program:
*Host Defense Community Herbal – 2 capsules daily
*Vitamin C – 1,000 mg Daily
*Telomere – 2 gel caps daily
*Vit E – 400 iu daily
*Clinical Nutrients Multivite/Minineral Daily
*Vitamin D3 – daily amount based on blood testing

This page is added to every day!
Return here for all things related to COVID-19

Please read and follow:

1. Good hygiene practices
2. Boost your immunity Now
3. Get all of the items listed
4. Awaken to your bodies natural immunity & intelligence

Stay as in “Joy” as much as possible!

Thrive 360 Community Preparations for Coronavirus

https://www.facebook.com/DoctorSarahLarsen/videos/186741346083040/

Stay isolated – self-imposed until you are the highest level of joy – where no illness can touch you!

Prepare Now and Join Miracle Makers
https://www.miraclemakersacademy.com/

Here’s what you need to know:

The Calm Before The Storm – Coronavirus Cases Set To Explode Higher

What are the symptoms of COVID-19?

Fever, cough, and shortness of breath.

Symptoms of the coronavirus may appear in as few as 2 days or as long as 14 after exposure, according to the CDC.

Can I have the coronavirus without seeing symptoms?

Though Chinese officials said that there is evidence of the virus being spread before symptoms show, nothing has been proven yet. If that is true, it would make the disease harder to contain.

Ray said that it’s been confirmed that there the virus’s symptoms are on a range of intensity. Symptoms can seem like a cold or feel like pneumonia. What’s not known yet is the virus’s incubation period — how long for symptoms to show after someone contracts the virus — and the window of contagion — how long the virus is contagious.

How is it spread?

Early on, many of the patients in the outbreak of coronavirus had some link to a large seafood and live animal market, suggesting animal-to-person spread, the CDC says.

Use your Miracle Making Powers to visualize Coronavirus as a normal cold with a lot of fear creating illness!

What to have on hand:

1. Elderberry Syrup Recipe

Ingredients-

  • 10 oz dried elderberries
  • 3 oz ginger root
  • 2 oz osha root (lung tonic)*
  • 2.8 oz Oregon grape root (dried)
  • 2 c raw local honey
  • 10 c water
  • ¾ c brandy or rum

*[Becca commented] I do not usually add the osha as my kids hate the taste.

Cooking –

Combine all herbs and water in stainless steel pot, and simmer 45 minutes. Stir frequently.

Let cool

Strain mixture through cheesecloth or clean cotton cloth into another stainless steel pot-squeeze out as much liquid as possible from the herb mix

Add honey and brandy to the strained liquid and warm over low heat, stirring frequently

Pour syrup into glass jars and label

Note- the alcohol is added as a preservative so the syrup does not need to be refrigerated, but it should be stored in a cool, dark place

Dosing –

Take 1 Tbsp up to 3 x daily during illness. I also take a dose as soon as I begin to feel just the hint of an illness and it usually stops it completely.

All ingredients can be ordered from http://www.mountainroseherbs.com/

2. Mask and googles

The CDC does recommend that healthcare providers wear N95 respirators, face masks that filter at least 95% of airborne particles if they treat a patient infected with the novel coronavirus.

3. Practice Good Hygiene:

Wash your hands often and share Tea Tree Oil with everyone before shaking hands

Hand Sanitizer made with Tea tree oil makes an ideal natural hand sanitizer. …..

Tea tree oil, also known as melaleuca oil, is an essential oil distilled from the leaves of the native Australian plant Melaleuca alternifolia.

Today, tea tree oil is commonly found in cosmetics, topical medicines, and household products.

Fast facts about tea tree oil

  • Tea tree oil is distilled from the leaves of the Melaleuca alternifolia plant, found in Australia.
  • The oil possesses antibacterial, anti-inflammatory, antiviral, and antifungal properties.
  • Tea tree oil should never be swallowed.

Essential Oils to have at home

  1. Bergamot oil is effective against flu viruses as a vapor after just 10 minutes of exposure.
  2. Eucalyptus oil shows anti-viral activity as a vapor.
  3. Red thyme oil is effective against flu viruses as a liquid phase.
  4. Cinnamon leaf oil also shows antiviral activity as a liquid.
  5. Tea tree oil is effective against the flu virus within 5 to 10 minutes of exposure, as found in another study.
  6. Lemon balm is also shown to prevent the avian influenza (bird flu) virus from reproducing

ClO2 – for water purifying

Chlorine Dioxide and it’s not bleach,

Known as chlorine dioxide, this solution has been approved by the U.S. Food and Drug Administration (FDA) for use in food manufacturing as well as a disinfectant for water. Both the Environmental Protection Agency (EPA) and the World Health Organization (WHO) have also endorsed it for water purification.

A simple, safe and easily accessible mineral solution made from one chlorine atom and two oxygen atoms is saving lives all across the world.

Chlorine dioxide, for starters, doesn’t even contain sodium as is found in bleach. It’s an entirely different molecule made from different elements. 

What Exactly is Chlorine Dioxide?

Chlorine dioxide (CD) is a member of the pro-oxidant family. There are 4 pro-oxidants: chlorine dioxide (this is the weakest), oxygen that we breathe, ozone, and hydrogen peroxide.

Pro-oxidants do not cause oxidative stress. They reduce oxidative stress by killing the pathogens that cause it.

CD kills pathogens but does not harm healthy cells or tissues. It reduces overall inflammation. It is antibacterial, antifungal, anti-viral, anti-helminthic (parasites), and neutralizes heavy metals.

It is not a chelator, but it makes heavy metals available to any chelator that is used at the same time to remove heavy metals.

Because CD is a gas that is dissolved in water, CD can pass through the cell membranes of microbes and cause their death. It does this by taking electrons from mold, candida, and bacteria leaving them to break apart or ooze themselves to death.

In a research study, CD was shown to reduce 98% of bacteria and fungi such as E. coli, candida albicans, and streptococcus (strep which is found in PANDAS, PANS, and PITAND).

When a person drinks CD, it is dispersed throughout the body and is not limited by the blood-brain barrier, veins, or the GI tract.

Where can a Person get Chlorine Dioxide?

Chlorine dioxide is made at home prior to using it because it has a short shelf life.

The Internet and YouTube are filled with widely differing methods for making CD and it is often not clear what is real and what is intended to be misleading information.

The chlorine dioxide kit recommended contains one bottle of 22.4% sodium chlorite solution and one bottle 4% HCl (hydrochloric acid). It is found at https://wps4sale.com/product/wps-with-hcl-kit-4oz/. 

The two liquid chemicals are added together in equal amounts. Each must be in the proper dilution before mixing. One drop of each chemical is placed in a dry shot glass with a rounded bottom and mixed for one minute. This makes 1 drop of chlorine dioxide.

Notes about using Chlorine Dioxide

It can be used in a wide variety of applications. It can be swallowed, or added to a bath or put in a humidifier. It can be used in the eyes, ears, nose, or as a spray on the skin. A powerful option is to use it as an enema.

If the CD will be consumed by drinking, then one drop of CD is mixed with water and divided into 8 or 16 equal size doses. The doses are consumed throughout the day. The goal is to start out with a very low dose and to proceed very slowly, because it will be killing pathogens. [3]

Dr. Sarah's Blog

Coronavirus is an RNA Virus | COVID-19 and The Essential Nutrition to Protect Yourself

January 29, 2020 by Dr. Sarah Larsen 3 Comments

Updated Jan 22. 2021

Thank you: Front Line COVID-19
Critical Care Alliance

What can you do to prevent getting COVID-19?

Dr. Paul Marik, a founding member of the Front Line COVID-19 Critical Care Alliance, takes you through all of the steps you can take to limit your chances getting COVID-19. At the heart of it is the FLCCC Alliance’s I-Mask+ Prophylaxis & Early Outpatient Treatment Protocol. Its components include ivermectin, which has been shown in study after study to prevent COVID-19, and to keep patients who become symptomatic from progressing into more serious COVID-19 illness. Watch and SHARE please!

https://player.vimeo.com/video/486829903

The FLCCC Alliance

As a group of colleagues with over 200 years of combined experience in Critical Care and Emergency Medicine, as well as long-standing shared interests in developing effective treatments for critical illnesses including sepsis, we, the FLCCC Alliance, formed a working group devoted to creating a treatment protocol against COVID-19 in early March 2020. The protocol we devised, called MATH+, is intended for use in hospitalized patients, with an emphasis on early initiation—as soon as a patient develops the need for supplemental oxygen.

The success of the MATH+ hospital treatment protocol is detailed in the team’s  Clinical and Scientific Rationale for the MATH+ Hospital Treatment Protocol for COVID-19 published in the Journal of Intensive Care Medicine in December 2020. The two hospitals that adopted the MATH+ protocol and initiated it early in the treatment of COVID-19 patients (in ICU) averaged only a 5.1% mortality rate, compared with mortality rates reported from other hospitals of between 10–30% during the same time periods, depending on whether corticosteroids were used. Information about the team’s more recent I-MASK+ formula for prophylaxis and early outpatient treatment of COVID-19 can be found here.

We would like to emphasize that the FLCCC Alliance is not opposed to vaccination, and furthermore supports policies such as mask wearing, social distancing, and hand hygiene to prevent the further spread of the SARS-CoV-2 virus. Our treatment proposals are designed, first of all, to mitigate the effects of the pandemic until it is overcome, and to allow for an earlier return to daily life.

My brother in Law – Jeff Larsen- has been diagnosed with Covid Lung Disease! Many times on the edge. many times we have asked for clergy.

Many days we have embraced the miracle of his life ….

Since before Thanksgiving 2020 -we have been as a family – a global family – a Miracle Making – Heart opening experience!

Thank you for your prayers! I believe it is your prayers as well as his incredible team at St. Josephs!

YOU ARE SAVING LIVES when you learn what is written on this page!

Thank you for your prayers! Greg writes an update here: https://www.facebook.com/photo/?fbid=10224558847744627&set=a.2104340934063

Please Watch Dr. Kory

https://player.vimeo.com/video/490351508

NIH (National Institutes of Health) Revises Treatment Guidelines for Ivermectin for the Treatment of COVID-19

Ivermectin is Now a Treatment Option for Health Care Providers!

Jan 14, 2021 – One week after Dr. Paul Marik and Dr. Pierre Kory – founding members of the Front Line Covid-19 Critical Care Alliance (FLCCC) – along with Dr. Andrew Hill, researcher and consultant to the World Health Organization (WHO), presented their data before the NIH Treatment Guidelines Panel, the NIH has upgraded their recommen­da­tion and now considers Ivermectin an option for use in COVID-19.

Their recommendation has now been upgraded to the same level as those for widely used monoclonal antibodies & convalescent plasma, which is a “neither for nor against” recommen­da­tion. The significance of this change is that the NIH has decided to no longer recommend against the use of ivermectin in the treatment of COVID-19 by the nation’s health care providers. A consequence of this change is that ivermectin has now been made a clear therapeutic option for patients.

MATH+ Hospital Treatment Protocol for COVID-19

Read more here: https://covid19criticalcare.com/math-hospital-treatment/pdf-translations/

The MATH+ Hospital Treatment Protocol for COVID-19 is designed for hospitalized patients, to be initiated as soon as possible after they develop respiratory difficulty and require oxygen supplementation. The three core pathophysiologic processes that have been identified are severe hypoxemia, hyperinflammation, and hypercoagulability. This combination medication protocol is designed to counteract these processes either through the use of single agents or in synergistic actions. A unique insight into this disease made by members of our group is that the majority of patients initially present with an inflammatory reaction in the lungs called “organizing pneumonia,” which is the body’s reaction to injury and is profoundly responsive to corticosteroid therapy. If the organizing pneumonia response is left untreated or presents as a rapidly progressive sub-type, a condition called Acute Respiratory Distress Syndrome (ARDS) follows.

The two main therapies that can reverse and/or mitigate the extreme inflammation causing ARDS are the combination of the corticosteroid Methylprednisolone and the antioxidant Ascorbic acid, which is given intravenously and in high doses. Both of these medicines have multiple synergistic physiologic effects and have  been shown in multiple randomized controlled trials to improve survival in ARDS, particularly when given early in the disease. Thiamine is given to optimize cellular oxygen utilization and energy consumption, protecting the heart, brain, and immune system. Given the numerous clinical and scientific investigations that have demonstrated consistent, reproducible, and excessive levels of hyper-coagulation, particularly in the severely ill, the anticoagulant Heparin is used to both prevent and help in dissolving blood clots that appear with a very high frequency. The “+” sign indicates several important co-interventions that have a combination of strong physiologic rationale with existing or emerging pre-clinical and clinical data to support their use in similar conditions or in COVID-19 itself, and all with a well-established safety profile. Such adjunctive therapies are continuously being evaluated and amended as the published medical evidence evolves.

Timing is a critical factor in the efficacy of MATH+ and to achieving successful outcomes in patients ill with COVID-19. Patients must go to the hospital as soon as they experience difficulty breathing or have a low oxygen level. The MATH+ protocol should be administered soon after a patient meets criteria for oxygen supplementation (within the first hours after arrival in the hospital), in order to achieve maximal efficacy.  Delayed therapy can lead to complications such as the need for mechanical ventilation. If administered early, the MATH+ formula of FDA-approved, safe, inexpensive, and readily available drugs may eliminate the need for ICU beds and mechanical ventilators and return patients to health.

Jan 17, 2021 | PUBLIC STATEMENT

 FLCCC Alliance Response to the NIH Guideline Committee Recommendation on Ivermectin use in COVID-19 dated January 14th, 2021

https://player.vimeo.com/video/490351508?dnt=1&app_id=122963

Dr. Pierre Kory testifies to Senate Committee about Ivermectin, Dec. 8, 2020

Appearing as a witness on Dec. 8, 2020, before the Senate Committee on Homeland Security and Governmental Affairs—which held a hearing on “Early Outpatient Treatment: An Essential Part of a COVID-19 Solution”— Dr. Pierre Kory, President of the Frontline COVID-19 Critical Care Alliance (FLCCC), called for the government to swiftly review the already expansive and still rapidly emerging medical evidence on Ivermectin. Read More

Jan 7, 2021 – Press Release
 FLCCC Alliance Invited to the NIH COVID-19 Treatment Guidelines Panel to Present Latest Data on Ivermectin
On January 6, 2021, our Drs. Pierre Kory and Paul Marik, founding members of the FLCCC Alliance, appeared before the National Institutes of Health COVID-19 Treatment Guidelines Panel to urge review of current data and an updated NIH guidance.

Dec 15, 2020 – now published:
 Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19
FLCCC Alliance peer-reviewed paper published in the Journal of Intensive Care Medicine. The protocol described in this paper potentially offers a life-saving approach to the management of hospitalized COVID-19 patients. The MATH+ protocol offers an inexpensive combination of medicines with well-known safety profiles based on strong physiologic rationale and an increasing clinical evidence base.

“The I-MASK+ protocol will revolutionize the treatment of COVID-19”

Dr. Paul Marik (Oct. 30, 2020)

The Front Line COVID-19 Critical Care Alliance has now developed a prophylactic and early outpatient combination treatment protocol for COVID-19 called I-Mask+. This protocol is centered around the use of ivermectin, a well-known anti-parasite drug. Ivermectin has recently discovered anti-viral and anti-inflammatory properties and a rapidly growing published medical evidence base demonstrating its unique and highly potent ability to inhibit SARS-CoV-2 replication.

Please visit these links to get the full picture:

  • I-MASK+ Prophylaxis & Early Outpatient Treatment Protocol for COVID-19
  • Our comprehensive review of the emerging evidence for Ivermectin use in our I-MASK+ protocol 
  • A one-page summary of the scientific review on ivermectin above 
  • Dr. Paul Marik’s comprehensive meta-analysis of COVID-19 therapeutics 
  • An introductory video explaining the review on Ivermectin by Dr. Pierre Kory 
  • Dr. Paul Marik’s recent lecture on I-MASK+ 
  • Invited Grand Rounds Lecture on ivermectin by Pierre Kory 

In March, 2020 we first published our MATH+ Treatment Protocol for COVID-19, intended for hospitalized patients. The recently developed I-MASK+ Prophylaxis & Early Outpatient Treatment Protocol for COVID-19 is instead directed for use as a prophylaxis and in early outpatient treatment after contracting COVID-19. The protocols thus complement each other, and both are physiologic-based combination treatment regimens developed by leaders in critical care medicine. All component medicines are FDA-approved (except ivermectin), inexpensive, readily available and have been used for decades with well-established safety profiles.

  • An FLCCC Alliance guide to the management of COVID-19  – An overview of the MATH+ and I-MASK+ protocols

Greg Larsen with his brother Early Nov 2020

RNA virus: A virus in which the genetic material is RNA. The RNA may be either double- or single-stranded. … Class IV viruses have a positive single-stranded RNA genome, the genome itself acting as mRNA (messenger RNA. Class V viruses have a negative single-stranded RNA genome used as a template for mRNA synthesis.

**UPDATE** Please scroll down for recommendations on nutritional supplements and holistic approaches to boost your immune system!

Viruses are smaller than bacteria and can’t survive without a living host. A virus attaches itself to cells and usually reprograms them to reproduce itself. Also, unlike bacteria, most viruses do cause disease. Some virus-caused diseases include the common cold, AIDS, herpes, and chickenpox.

Coronaviruses have helically symmetrical nucleocapsids, which is uncommon among positive-sense RNA viruses, but far more common for negative-sense RNA viruses. Coronavirus virus particles contain four main structural proteins. … The M protein is the most abundant structural protein in the virion.

Negative-sense ssRNA viruses (Group V) must have their genome copied by an RNA replicase to form positive-sense RNA. This means that the virus must bring along with it the RNA replicase enzyme. The positive-sense RNA molecule then acts as viral mRNA, which is translated into proteins by the host ribosomes.

Read More

Dr. Sarah's Blog, Podcast

Day 6 | 21 Days of Abundance Consciousness Challenge | Deepak Chopra

Love you completely for sticking with this!

Today, be in the moment, relax, and allow for more time today – it’s the most writing you’ll do!

Day 6

Congratulations to you, you have created your own abundant groups! Woohoo!! 

Now we enter what’s called Operating Mode

?

I recommend staying organized with your groups and remaining timely.

Observe the order and terms of assignments and use the original texts, updating the dates as appropriate.

Remember that we only transmit what we received ourselves! 

If you have questions about the conduct of your group, please text me in private. 🙂

We continue to work with our groups and begin the 6th day.

*Task*

Statement:

“I, (full name, last name), am starting a new relationship with money today.
Money is good, pure, useful and necessary for my prosperity and growth, for my satisfaction and abundance.

Money brings positive things to my life. The success that I experience in life brings me money and happiness, for me and my loved ones.

I deserve to flourish and have a lot of money.
Money is my friend and the value of my investments in it is growing every day.

Success and money accompany me, here and now.

I ask my parents, grandparents, and ancestors to the very origins of the tribe, who had difficulties due to lack of money, to bless me as I choose to live differently.

And I ask my parents, grandparents, and ancestors to inspire me to the very origins of the family, who lived in abundance and prosperity.”

Write this statement 10 times in your notebook by hand. If you have questions about the phrasing, reach out Personally. 

After that record yourself reading this statement with soul, expression and sense of attachment, i.e. sincerely, on audio or video.

This task is the longest in our journey, it can take about an hour.  
Before performing – sit comfortably, relax, inhale several times slowly and deeply through the nose and exhale as slowly through the nose.

Our brain learns through repetition and rehearsal.
Therefore, tune in to connect with what you will write.

All of this is necessary to harmonize your internal relationship with money.

*Phrase*

Everything I desire is within me!*

*Mantra of the Day*

Ram… ram… ram…
Ram… ram… ram

As a reminder, it is completely normal to experience discomfort and resistance to some tasks. This journey highlights your blocks and negative programming clearly so that you can see what is stopping you from living the abundant life that you desire. 

You all are doing amazing! 

Keep it up!! Have a wonderful day! Wishing you clarity -Welcome home to you! 

Day 0 | 21-Day Creating Abundance Meditation Challenge

Day 1 | 21-Day Creating Abundance Meditation Challenge

Day 2 | 21-Day Creating Abundance Meditation Challenge

Day 3 | 21-Day Creating Abundance Meditation Challenge

Day 4 | 21-Day Creating Abundance Meditation Challenge

Day 5 | 21-Day Creating Abundance Meditation Challenge

Day 6 | 21-Day Creating Abundance Meditation Challenge

Day 7 | 21-Day Creating Abundance Meditation Challenge

Day 8 | 21-Day Creating Abundance Meditation Challenge

Day 9 | 21-Day Creating Abundance Meditation Challenge

Day 10 | 21-Day Creating Abundance Meditation Challenge

Day 11 | 21-Day Creating Abundance Meditation Challenge

Day 12 | 21-Day Creating Abundance Meditation Challenge

Day 13 | 21-Day Creating Abundance Meditation Challenge

Day 14 | 21-Day Creating Abundance Meditation Challenge

Day 15 | 21-Day Creating Abundance Meditation Challenge

Day 16 | 21-Day Creating Abundance Meditation Challenge

Day 17 | 21-Day Creating Abundance Meditation Challenge

Day 18 | 21-Day Creating Abundance Meditation Challenge

Day 19 | 21-Day Creating Abundance Meditation Challenge

Day 20 | 21-Day Creating Abundance Meditation Challenge

Day 21 | 21-Day Creating Abundance Meditation Challenge

Day 1 | 21 Days of Abundance Consciousness Challenge | Deepak Chopra

In this meditation, Deepak Chopra gives an overview of the challenge and explains the reality of abundance.

You can connect with your true “Nature of Abundance” and how you can begin to open your eyes to the abundance that is already before you.

The centering thought for this meditation is:

Today, I behold all of the abundance that surrounds me.

As you work through the meditation, let go of your thoughts, and begin to observe the breath, noticing how you become more relaxed with each breath.

You can use the so-hum mantra to deepen your relaxation and center yourself into a feeling of peace.

When you feel at peace, begin to think through the idea for the day: “Today, I behold all of the abundance that surrounds me.”

The abundance meditations are made available through the Chopra Center. 

Day 1

After you complete the task, please write “Day 1 Done.”   

No more writing is necessary!   You have 24 hours (plus a little leeway) to complete the task.  

I highly recommend doing the meditation and the task at the beginning of the day, if possible.  It changes the course of the day!  

*Task*

 In your new notebook, make a list of 50 people that have influenced your life.  

They can be both living and already departed people, your relatives, friends, and celebrities, writers and personalities whom you do not necessarily know personally.  

Everyone who has influenced you, and contributed to your growth & development.  

The list must have at least 50 names.  

In the process of making a list, think about why you chose the person. What has changed in your life for the better?   

Move calmly and thoughtfully. 

Remember the best things about each person on the list and what they bring into your life.  

Trust in the process!  

I recommend putting the phone in airplane mode at this time so that no one will interfere with you (children and everyone around you too 🙂 – as much as is realistic of course )  

Your list may be more than 50 people. But not less!  

PHRASE OF THE DAY: 

* Today I behold the abundance that surrounds me *

This should also be written in your notebook and remembered during the day as often as possible.  

This meditation can be done before or after the task. It’s up to you!   

This is the Mantra you will repeat during meditation:

So Hum

So Hum

DAY 1 RECAP:  

1. Meditation: Listen to the audio. Repeat the mantra.  

2. Write the phrase of the day in your notebook: “Today I behold all the abundance that surrounds me.”   Remember it during the day.  

3. Complete the assignment in a notebook – make a list of 50 people who have influenced your development.  

4. I highly recommend staying on top of each daily task if possible.  

Have a great evening and an even better day!!

P.S. Note from Dr. Sarah

I received the 21 Days of Abundance Meditation Challenge from a friend on Whatsapp! On Day 5 I began inviting people into groups to share the message, frequency, and miracles!

I created these pages to make it easy for those Miracle Makers that needed a way to share with their tribe extra easy!

I later learned the program is for sale by the Chopra Center and no longer free.

Opps… I want you to finish the program and purchase this or another program from The Chopra Center.

I care about the integrity of you completing this program.

I especially want to do the right thing by The Chopra Center and this is what I believe is what is best for Dr. Chopra as well!

Please purchasing something from The Chopra Center in alignment with your heart’s desire! Let’s make Miracles for everyone!

Dr. Deepak Chopra carries the frequency of Abundance in his family lineage. He is a transmitter of the frequency!

He gave it to us in this challenge and in the guided meditations:
This incredible work, meditation, and challenge belong to Deepak Chopra.

I am grateful to be able to share it with you!

Here is a link to purchase it:

https://chopracentermeditation.com/store/product/6/creating_abundance_streaming

P.S.S. Day 0 has all the instructions. Please see link below!



Day 0 | 21-Day Creating Abundance Meditation Challenge

Day 1 | 21-Day Creating Abundance Meditation Challenge

Day 2 | 21-Day Creating Abundance Meditation Challenge

Day 3 | 21-Day Creating Abundance Meditation Challenge

Day 4 | 21-Day Creating Abundance Meditation Challenge

Day 5 | 21-Day Creating Abundance Meditation Challenge

Day 6 | 21-Day Creating Abundance Meditation Challenge

Day 7 | 21-Day Creating Abundance Meditation Challenge

Day 8 | 21-Day Creating Abundance Meditation Challenge

Day 9 | 21-Day Creating Abundance Meditation Challenge

Day 10 | 21-Day Creating Abundance Meditation Challenge

Day 11 | 21-Day Creating Abundance Meditation Challenge

Day 12 | 21-Day Creating Abundance Meditation Challenge

Day 13 | 21-Day Creating Abundance Meditation Challenge

Day 14 | 21-Day Creating Abundance Meditation Challenge

Day 15 | 21-Day Creating Abundance Meditation Challenge

Day 16 | 21-Day Creating Abundance Meditation Challenge

Day 17 | 21-Day Creating Abundance Meditation Challenge

Day 18 | 21-Day Creating Abundance Meditation Challenge

Day 19 | 21-Day Creating Abundance Meditation Challenge

Day 20 | 21-Day Creating Abundance Meditation Challenge

Day 21 | 21-Day Creating Abundance Meditation Challenge

How do I reverse my age? How do I stay young and healthy?

Focus on What markers can help access

Hallmarks

While Sinclair was in Guarente’s lab, David Sinclair discovered that Sirtuin 1 (called sir2 in yeast) slows aging in yeast by reducing the accumulation of extrachromosomal rDNA circles.

Others working in the lab at the time identified NAD as an essential cofactor for sirtuin function.

To prove that aging is a problem we can solve—and figure out how to stop. He argues that we can slow down the aging process, and in some cases even reverse it, by putting our body through “healthy stressors” that increase NAD levels and promote sirtuin activity. The role of sirtuins in aging is now fairly well accepted, but the idea that we can reactivate them (and how best to do so) is still being worked out.


Supplements and Recommendations

Nmn supplementsNMN is a direct and powerful (Nicotinamide Adenine Dinucleotide) NAD+ supplement. NMN was the actual compound used by scientists to reverse several longevity bio-markers in old mice, sparking worldwide interest in NAD research.

David Sinclair Takes:

  • Resveratrol – 1g/daily – mornings with yogurt (see where to buy)
  • Nicotinamide Mononucleotide (NMN) – 1g/daily – mornings (see where to buy)
  • Metformin (prescription drug) – 1g/daily in the evenings – except on days when exercising
  • Multivitamins? Only vitamin D3 with K2, he aims to get the rest from his diet
  • Statin (prescription drug) – taken since his early 20s due to family history of cardiovascular disease
  • Aspirin – 83mg daily

– Started taking resveratrol around 2004, and added NMN & Metformin approximately 3 years ago
– Resveratrol, NMN & Metformin doses come via David’s recently released book; Lifespan
– Daily vitamin K2, D3 and aspirin all also mentioned in his book Lifespan
– David discussed using a statin in his Jan 2019 Joe Rogan interview (link), but didn’t mention it in his book

His studies showed that without fat, resveratrol absorption was 5x lower. So consumption with yogurt (or another fat source) is important. David clarified on the recent podcast with Rhonda Patrick that the NMN doesn’t need to be taken with a fat source – he specifically mentions taking his NMN in capsules, downed with a glass of water in the morning.

What do Resveratrol & NMN do in relation to living longer?

David describes resveratrol and NMN as critical for the activation of sirtuin genes. Sirtuins play a key role in functions that help us to live longer – such as DNA repair.

He describes resveratrol as the “accelerator pedal” for the sirtuin genes (increasing their activation), and NMN as the fuel. Without “fuel”, resveratrol won’t work. The reason that resveratrol won’t work effectively without NMN, is that sirtuin activation requires youthful NAD levels, but by 50 years old, we have about half the level of NAD we had in our 20s (NAD being a molecule that is essential to energy production in our cells).

So in effect, you take resveratrol to increase activation of the sirtuin genes, and NMN to ensure the sirtuins have enough energy to work properly.

What else is David doing to stay healthy?

  • Intermittent fasting – skipping breakfast and/or lunch where possible. Helped by lots of green tea
  • Running 1-2x/week low impact and high intensity (using a curved treadmill such as Woodway)
  • Weight lifting (ideally!) 2-3x/week
  • Sauna weekly
  • Coffee in the morning (once per day), then green tea after that

Below we’ll dig deeper into the 3 longevity supplements David takes; NMN, Resveratrol & Metformin.

Contents [hide]

  • 1 Resveratrol
    • 1.1 Resveratrol – Where to buy?
    • 1.2 Resveratrol – Storage
    • 1.3 Homemade Yogurt
  • 2 NMN – Nicotinamide Mononucleotide
    • 2.1 NMN – Where to buy?
    • 2.2 NMN Price & Bioavailability
    • 2.3 What does David think of Nicotinamide Riboside (NR)?
    • 2.4 NR – Where to buy?
    • 2.5 NR & NMN Storage
    • 2.6 NMN/NR & Methyl Group Depletion?
  • 3 Metformin
    • 3.1 Metformin – Where to buy?
    • 3.2 Metformin – How often to take?
  • 4 How to (big picture) think about the molecules David takes?
  • 5 To Conclude…
    • 5.0.1 See Post Sources Below:

Resveratrol

Resveratrol is a molecule that’s found (in small amounts) in the skin of foods like grapes, blueberries, raspberries, mulberries, and peanuts. If you remember the “hype” some time ago around red wine being healthy, part of that came because it contains tiny amounts of resveratrol. Unfortunately all foods sources contain tiny amounts, so we need to take it in a concentrated supplement form for it to be useful.

There’s actually a fair amount of controversy around the potential benefits of resveratrol. For example this 2019 literature review is quite critical of the health claims:

  • Resveratrol: Twenty Years of Growth, Development and Controversy

Whereas this paper (admittedly co-authored by David Sinclair), points to benefits:

  • Therapeutic potential of resveratrol: the in vivo evidence

In that paper they hypothesize that resveratrol acts a “caloric restriction memetic”, which activates beneficial cellular pathways.

Given that there are scientists much smarter than me on both sides of the fence, I find it hard to draw a conclusion. But certainly it’s interesting that a scientist like David has taken it since 2003 – and continues to do so to this day.

Left pic = 2009 (source), right pic = 2019 (source)

Resveratrol – Where to buy?

Whilst David’s resveratrol comes from excess product leftover from lab experiments, not all of us have this luxury! Therefore we are forced to look online. If you pop resveratrol into an Amazon search, you’ll find a host of different options, many of (potentially) dubious quality.

The first thing to note is that we should be looking for trans-resveratrol, not cis-resveratrol.

From David’s studies, cis-Resveratrol did not activate the sirtuin enzyme, but trans-Resveratrol did.

Next, the purity of the trans-resveratrol is important, we’re looking for 98%+. David mentions this at 1:17:54 of his Ben Greenfield interview, noting that 50% purity can even give diarrhea, because there’s other stuff that comes along with the molecule. He also confirms that Polygonum cuspidatum (Japanese Knotweed) is a good source for the resveratrol.

To get closer to the quality that David is likely taking, we can look at research published by an old company of his; Sirtris (who were sold to GSK for $720 million). In this paper they were doing clinical tests on a formulation of resveratrol they call SRT501. Noting that:

Due to the poor aqueous solubility exhibited by resveratrol, digestive absorption is greatly influenced by drug dissolution rate. In an effort to increase absorption across the gastro-intestinal tract and thus systemically available parent compound, there has been considerable interest in the pharmaceutical manipulation of resveratrol. Decreasing the particle size of such chemicals can improve their rate of dissolution and thus their absorption. Therefore, the aim of this clinical study was to investigate whether consumption of SRT501, a micronized resveratrol formulation designed by Sirtris, a GSK Company is safe and generates measurable and pharmacologically active levels of parent agent in the circulation and in the liver.

That’s a wordy quote from the paper, but in essence, they were testing a micronized resveratrol formulation against a non-micronized version. Their study found that levels of resveratrol in the blood were 3.6x greater when using the micronized formulation, and other markers they were comparing also improved.

We see this with other molecules too; where reducing particle size increases bioavailability. For example with curcumin, whose absorption can be improved through micronization (for example Theracurmin). So this makes sense.

Searching Amazon for “micronized resveratrol” suddenly shrinks the options to just a few, including MegaResveratrol. However, I noticed something on the page for the Rich Roll interview with David Sinclair. He lists a micronized resveratrol by RevGenetics. This was interesting because during the interview Rich asks David where to get the supplements he takes, and David told him they’d talk about it after the podcast. Maybe RevGenetics was a brand that David mentioned post interview (possible), or perhaps it was just a brand Rich “plucked” from a Google search. Impossible to know without further info.

That said, I looked into RevGenetics a little more, and they certainly seem legitimate, with a high rating on ShopperApproved. They focus on longevity molecules and have been selling resveratrol since 2006. They offer a micronized 98% trans-resveratrol that comes in powder form, and thus could be taken in the morning with yogurt, as David does. It’s named M98 Super Micronized Resveratrol.

If like me, you’re curious about the daily cost… at 1g/day it works out at $3/day ($75 per 25g tub). If you buy 2 or 3 tubs you get a discount, and it comes down to $67.50 per tub, so $2.70/day.

Note: Whichever source of trans-resveratrol you take, ensure to mix it with a fat source (such as yogurt or olive oil) in order to maximize bioavailability.

Resveratrol – Storage

David mentions in his interview with Rhonda Patrick a few nuances around the storage of resveratrol:

  • Resveratrol is light sensitive, and when left exposed to light it turns brown. They found that brown resveratrol no longer works correctly.
  • Ideally resveratrol should be kept in the cold and dark – for example, in a sealed container in the fridge.

Homemade Yogurt

David Sinclair Homemade Yogurt –

NMN – Nicotinamide Mononucleotide

NMN falls into a category of supplements, along with Nicotinamide Riboside (NR), referred to as “NAD boosters” – which have become increasingly popular.

NAD is required for every cell of our body to help facilitate energy production. As we age, the amount of NAD our cells produce declines, and less NAD = reduced cellular function. According to David, at 50, you have about half as much NAD as at age 20.

The hope is that by supplementing precursors we can boost the cellular level of NAD closer to youthful levels.

There’s little to no doubt in the research community that we need to restore NAD function; but the jury is still out on what the best method will be. Currently David has his eggs in the basket of NMN.

NMN – Where to buy?

David’s NMN powder comes from excess product left over from lab experiments. This is good to know, but doesn’t help us when it comes to sourcing some. Below we will look at various possible buying options.

Potential considerations when buying include:

  • Accuracy – is the product you’re getting actually NMN?
  • Purity – assuming it is NMN, how pure is it? 90%… 95%…?
  • Contaminants – does it contain any contaminants such as heavy metals?
  • Fillers – are any fillers used, and if so, what % do they account for of the overall powder?

Assuming all the above are ok, the last crucial question is:

  • Price – how much does it cost per gram?

Searching online there are a large number of possible options. Without doing ones own 3rd party lab testing, it’s hard to evaluate the quality of products. What I’ve done below is put some of the more highly reviewed options into a table, calculated the approximate price per gram, and added links to any 3rd party analysis certificates the companies display.

ProductApproximate price per gram3rd Party Analysis Certificate?
ProHealth Longevity$5.33/gram ($80 / 15g)Yes – link
Double Wood$6.53/gram ($49 / 7.5g)Yes – link
Super NMN$6.08/gram ($152 / 25g)Yes – link
RevGenetics Advanced NMN$15.8/gram ($395 / 25g)Yes – link
No 3rd Party Analysis Certificate
Maac10$6.5/gram ($24 / 3.75g)None I can find
Genexx Powder (3x 15g tub)$5/gram ($225 / 45g)Their website says yes – but can’t find it

The above table provides a start, but for a detailed analysis table see this companion post.

– Price per gram
The average price per gram appears around $5-$6. For products dramatically lower in price than this, it would be worth exercising some caution around their quality.

– Capsulating the Powders
With the bulk powder versions of NMN above, you could put them into capsules yourself at home, using a cheap, but handy, capsule filling machine. Emulating the method David uses to take his NMN; in capsules swallowed with a glass of water.

– Testing
It’s perhaps worth noting that none of the companies (besides RevGenetics) have demonstrated testing for impurities such as heavy metals, solvents or bacteria – they only test for NMN purity.

NMN Price & Bioavailability

One thing that’s worth acknowledging is that NMN is currently a very expensive supplement, especially if you wanted to emulate David Sinclair’s dosage of 1g/day.

There are a few possible workarounds:Possible Price Workarounds – Click to Expand

What does David think of Nicotinamide Riboside (NR)?

Nicotinamide Riboside is a precursor to NAD, similar to NMN. David states in his book that his lab finds:

  • NMN a more stable molecule than NR
  • NMN is able to do some things in mice studies that NR can’t

That being said, he isn’t against NR, he’s just more optimistic on NMN being the better molecule for raising NAD in the long run. He notes in a blog post on NMN & NR that:

  • The science is further along for NR, but it’s too early to say which is better for humans.

NR – Where to buy?

The brand leader in sales of Nicotinamide Riboside is Chromadex’s Niagen (pictured above). Amongst Chromadex’s scientific advisors is Charles Brenner, who first discovered NR, and showed it could extend the life of yeast cells.

Niagen’s recommended serving size is 300mg (1 capsule) – which may be less efficient at raising NAD levels than 1g of NMN.

If we compare NR & NMN at a price per gram, they’re more similar than I expected. Niagen works out approximately $5.22/gram, and NMN is around $5-$6/gram depending on brand.

NR & NMN Storage

In David’s recent interview with Rhonda Patrick, he discussed details around storage, saying:

  • NR and NMN need to be kept cold (fridge or freezer) because they don’t have a long shelf life.
  • If they are kept on a shelf, and are not in a stabilized form, they can degrade into nicotinamide. This is sub-optimal because Nicotinamide can have the opposite of the desired effect, and actually inhibit the sirtuins1. He didn’t elaborate further on what a “stabilized form” means in this context, which would be interesting to know.
  • If NMN gets wet, or gets a bit of humidity in the bottle, its only a short time before it’s degrading. This may be the case with NR too (because it applies to many supplements), but when David explained this he was explicitly talking about NMN.

Since David explained this I’ve come to learn that Nicotinamide Riboside, when it its chloride form; Nicotinamide Riboside Chloride (as sold by Niagen), is in a stabilized form. This means that it doesn’t need to be kept cold to have an adequate shelf life. More on that below…Further Details on Stabilized NR – Click to Expand

NMN/NR & Methyl Group Depletion?

There has been some concern in the field that consuming NR or NMN could decrease the body’s methyl groups and lead to health problems. This section will discuss that issue…

So methylation itself, which utilizes methyl groups (CH?), is an essential process for a host of critical functions in the body, including regulation of gene expression and the removal of waste products.

Consuming Niacin derivatives (which includes NR and NMN) will require the body to use up methyl groups in order to later degrade and excrete them. There has been some discussion and concern that by increasing the amount of methylation the body needs to do (through supplementation of NR/NMN), we might deplete the body of methyl groups needed to carry out essential processes.

David discussed this in his podcast with Paul Saladino (see 44mins mark), acknowledging that Niacin derivates (including NR/NMN) require methylation for excretion, but asserting that at this stage the idea of methyl depletion is anecdotal, and not something that has been shown in any NR/NMN studies.

David says that in an abundance of caution he’s making sure he gets enough methyls in his diet. He mentions having used supplement called betaine (also known as trimethylglycine), which he says is a powder you can eat, and doesn’t taste too bad. But says what he now does is take a combination of methyl folate plus methyl B12 – and feels like that’s his best solution to this (potential) problem.

David doesn’t cite a particular brand that he uses, but options include Jarrow Methyl B-12/Methyl Folate & Pure Encapsulations – B12 Folate.

Methyl groups are primarily derived from nutrients in the diet, including; methionine (amino acid), folate (vitamin B9), choline, betaine, riboflavin (vitamin B2), pyridoxine (vitamin B6) and cobalamin (vitamin B12). For foods rich in these, see the table below (source):

  
CholineCauliflower, eggs, flax seeds, lentils, liver, peanuts, soybeans and wheat germ
Folate and folic acidAsparagus, cheese, eggs, fortified breads and cereals, legumes, liver, peanuts, oranges and spinach
MethionineDairy products, eggs, fish, meat, poultry and rice
Vitamin B2
(Riboflavin)
Cheese, eggs, meat and milk
Vitamin B6
(Pyridoxine)
Bananas, fish, grains, legumes, liver, meat, potatoes and poultry
Vitamin B12
(Cobalamin)
Eggs, fish, meat, poultry, dairy products

A further source to add to this discussion is the research done by Chromadex. They hold a patent on nicotinamide riboside production, and make Niagen. In a tweet thread by their chief scientific adviser Charles Brenner, he explains that Chromadex took the potential risk of NR depleting methyl groups seriously. To test this they performed a randomized double blind placebo controlled trial administering 100, 300, or 1,000?mg of NR over 56 days (study link). They used homocysteine levels as a proxy for methylation disturbance, and found no change to homocysteine in any of the dosage groups, including up to 1,000mg (see this image). If there was a shortage of methyl groups, they would have expected to homocysteine levels rise. Worth noting that study used NR, not NMN.

Metformin

Metformin is actually a relatively old drug, first discussed in medical literature in 1922, and studied in humans in the 1950s. It is derived from a plant called the French Lilac. It’s primary use in medicine is for the treatment of diabetes, thanks to its ability to decrease blood glucose levels in patients.

Because Metformin has been used for years, and has an established track record of safety, this makes it more attractive as a longevity drug. Molecules that are discovered today will need years of testing before they can even come close to rival the amount of data and “patient years” accumulated by metformin.

It’s thought the longevity benefits are at least in part derived from activation of the AMPK cellular pathway. This has a host of knock-on effects (visualized below), some of which are involved in beneficial processes like mediating inflammation and increasing autophagy (cellular cleanup).

AMPK pathway activation (image via this paper)

Metformin – Where to buy?

Metformin is a prescription drug, and thus needs to be acquired through a doctor’s prescription, at least in most countries. It isn’t (yet) considered a drug that can help improve healthspan or lifespan, and so you may need to find a forward thinking doctor if you want it prescribed for general health. Typically doctors only prescribe Metformin for blood sugar control issues (type 2 diabetes).

Metformin – How often to take?

Typically Metformin is taken daily – both by diabetics, and by people using it for healthspan extension. However, on the latest interview with Joe Rogan, they discussed a 2018 paper which showed metformin inhibits mitochondrial adaptations to aerobic exercise training. David explained that this makes sense, and its exactly metformin’s inhibition of mitochondrial function that leads to some of the health benefits. Specifically, they cause the cell to think it’s in a nutrient restricted state, and it turns on pathways typically reserved for times of scarcity. The function of these pathways is hypothesized to lead to better healthspan outcomes.

With this in mind, David opts to take metformin at night, so that come the morning, the mitochondrial inhibition is lessened. He also opts not to take it on days when he has been exercising.

How to (big picture) think about the molecules David takes?

We can attempt to summarise the function of the molecules David takes using 2 categories; 1) molecules that emulate fasting 2) molecules that boost existing function.

1) Molecules that emulate fasting

Both resveratrol and metformin can be described as molecules that trigger cells to exhibit characteristics similar to when fasting. Metformin activates AMP-Kinase, Resveratrol activates SIRT1 and AMP-Kinase.

Why is this beneficial?

Cells have evolved to operate in 2 main states; fed and unfed. In times of plenty, they will grow and multiply, and in times of scarcity, they will hunker down and focus on maintenance. Part of maintenance includes things like:

  • DNA repair
  • Removing and re-using non-functioning or superfluous cellular contents (autophagy)
  • Removing toxins

These are all important tasks, and it’s possible that when we exist in a constantly fed state, they don’t get performed as often as may be optimal.

Thus when David takes resveratrol and metformin, and undertakes intermittent fasting, he’s allowing for these fasting dependent processes to take place.

There may be other things going on too – but this is a big chunk of what’s happening.

2) Molecules that boost existing function

Whilst metformin and resveratrol are primarily aimed at preserving existing function, we have NMN which is taken to boost our NAD back to youthful levels.

Fasting can actually boost NAD levels too, but the intention is that using NAD precursors like NMN raises NAD higher and for longer than can be achieved otherwise.

TEST TO FIND BIOLOGICAL AGE

Commercial tests typically measure telomere lengths or amounts of telomeric DNA in a blood sample. Companies compare your telomeres to telomeres from people of similar age to try to determine the biological age of your blood cells. … In a way, telomeres follow the Goldilock’ principle.

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